Biography
Romain graduated from the Veterinary School of Alfort, France in 2002 and specialized in virology at the Intsitut Pasteur-Paris, where he obtained a Diploma in fundamental virology in 2002 and a PhD in virologye in 2005. Romain was then recruited as a Lecturer in Infectious Diseases at the Veterinary School of Toulouse in 2006, where he is teaching and leading research programs on avian Influenza viruses. Romain was a post-doctoral fellow at the University of Cambridge from 2010 to 2014.
Research
By combining the analysis of viral sequences obtained from virus isolated from various hosts and molecular biology tools enabling the genetic manipulation of Influenza viruses, Romain aims to identify mechanisms influencing pathogenicity and transmission of avian Influenza viruses in different host species. As part of the “Chaire de biosécurité » and a Young investigator grant from the French National Research Agency, his research project focuses on identifying how the host species (chicken vs ducks) influences the emergence of highly pathogenic avian Influenza viruses.
Selected publications
– M.M. Robblee, C.C. Kim, J. Porter Abate, M. Valdearcos, K.L.M. Sandlund, M.K. Shenoy, R. Volmer, T. Iwawaki, S.K. Koliwad, Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells, Cell Rep. 14 (2016) 2611–2623.
– R. Volmer, D. Ron, Lipid-dependent regulation of the unfolded protein response, Curr. Opin. Cell Biol. 33 (2015) 67–73.
– R. Volmer, K. van der Ploeg, D. Ron, Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains, Proc. Natl. Acad. Sci. 110 (2013) 4628–4633.
– S.M. Soubies, T.W. Hoffmann, G. Croville, T. Larcher, M. Ledevin, D. Soubieux, P. Quéré, J.-L. Guérin, D. Marc, R. Volmer, Deletion of the C-terminal ESEV domain of NS1 does not affect the replication of a low-pathogenic avian influenza virus H7N1 in ducks and chickens, J. Gen. Virol. 94 (2013) 50–58.
– T.W. Hoffmann, S. Munier, T. Larcher, D. Soubieux, M. Ledevin, E. Esnault, A. Tourdes, G. Croville, J.-L. Guérin, P. Quéré, R. Volmer, N. Naffakh, D. Marc, Length variations in the NA stalk of an H7N1 influenza virus have opposite effects on viral excretion in chickens and ducks, J. Virol. 86 (2012) 584–588.
– C. Volmer, S.M. Soubies, B. Grenier, J.-L. Guérin, R. Volmer, Immune response in the duck intestine following infection with low-pathogenic avian influenza viruses or stimulation with a Toll-like receptor 7 agonist administered orally, J. Gen. Virol. 92 (2011) 534–543.
– S.M. Soubies, C. Volmer, G. Croville, J. Loupias, B. Peralta, P. Costes, C. Lacroux, J.-L. Guérin, R. Volmer, Species-Specific Contribution of the Four C-Terminal Amino Acids of Influenza A Virus NS1 Protein to Virulence, J. Virol. 84 (2010) 6733–6747.
